P-329 Low expression of CPT1A in colorectal cancer infers favorable prognosis

CPT1A (Carnitine palmitoyl transferase 1 A), the key enzyme of Fatty acid oxidation (FAO), locates on outer mitochondrial membrane. Previous study had found that level is correlated with tumor progression in many kinds cancer. But this relationship has not been fully understood colorectal We analyzed expression cancer via GEPIA. evaluated association between and survival patients by Kaplan-Meier curve. Then, data sets were downloaded from TCGA. By using Cox regression, we several clinicopathologic characteristics associated overall TCGA patients. Furthermore, explored correlation immune infiltrates CIBERSORT. Pan-cancer analysis showed was lower most types. In significantly down-regulated tissue. The ROC curve suggested could be a potential diagnostic biomarker (AUC=0.928). Low better OS DFS. Further enrichment infiltration revealed high regulating some cell. A nomogram included T, N, M stage, CEA level, lymphatic invasion built. calibration probabilities predicted agreed well actual probabilities. tissues than normal It poor prognosis cell infiltration. And build to predict